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ALZET滲透泵是由這兩部分組成的
發(fā)布時(shí)間： 2021-04-24 點(diǎn)擊次數(shù)： 1037次ALZET滲透泵是體積只有膠囊大小的滲透壓泵，可植入實(shí)驗(yàn)動(dòng)物皮下或腹腔內(nèi)，直接或通過導(dǎo)管以 µl/小時(shí)的速度持續(xù)準(zhǔn)確地輸注測試藥劑。這種輸注根據(jù)所使用的泵，可以在動(dòng)物清醒無束縛條件下長持續(xù)6個(gè)星期。本產(chǎn)品一般由片芯和包衣膜兩部分組成，按照結(jié)構(gòu)特點(diǎn)，可將口服滲透泵制劑分為初級滲透泵和多室滲透泵兩類。初級滲透泵片芯中包含藥物和促滲透劑，包衣膜由高分子材料組成，包裹在片芯的表面。滲透泵片置于含水的環(huán)境中時(shí)，由于包衣膜內(nèi)外存在滲透壓差，水分通過包衣膜后形成藥物的溶液或混懸液，在包衣膜內(nèi)外滲透壓差的作用下，通過膜上的釋藥孔釋放。這種釋藥方式通常適用于在水中有一定溶解度的藥物。多室滲透泵制劑的片芯為雙層片，一層含有藥物及可溶解性輔料，另一層為遇水可膨脹的促滲透聚合物。這類滲透泵多適用于難溶性藥物滲透泵制劑的制備，釋藥過程由聚合物層膨脹產(chǎn)生推動(dòng)力而將藥物混懸液推出釋藥孔。產(chǎn)品特點(diǎn)：1、確保持續(xù)不間斷地均勻給藥；2、膠囊對半衰期短的藥物具有保護(hù)作用；3、可以向幾乎任何組織用藥；4、性價(jià)比很高的研究工具；5、確保連續(xù)不斷得暴露在預(yù)定水平的測試藥物下；6、可以執(zhí)行短效期的蛋白質(zhì)及縮氨酸給藥；7、提供了動(dòng)物慢性定量給藥的簡單方法；8、解決了夜間及周末給藥的不便困擾；9、減少了對實(shí)驗(yàn)動(dòng)物的操作和應(yīng)激影響；10、足夠小到可以應(yīng)用到小鼠，及年幼大鼠；11、體積小，可應(yīng)用于小鼠或幼年大鼠等小動(dòng)物實(shí)驗(yàn)；12、確保將藥物準(zhǔn)確輸送到靶部位，可以向幾乎任何組織用藥；13、使用方便，一次實(shí)驗(yàn)僅需一次給藥，不再需要夜間或周末實(shí)驗(yàn)；14、避免因重復(fù)給藥給動(dòng)物造成的應(yīng)激，從而減少非實(shí)驗(yàn)因素對實(shí)驗(yàn)結(jié)果的影響。
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